Original Research Articles (2010-2021)
- Single-cell RNA Sequencing Reveals a Role for Reactive Oxygen Species and Peroxiredoxins in Fatty-Acid-Induced Rat Beta-Cell Proliferation. Diabetes. 2022 Oct 3:db220121. BioRxiv link.
- Beta-cell mass expansion during puberty involves serotonin signaling and determines glucose homeostasis in adulthood. JCI Insight. 2022 Sep 15:e160854.
- Very Long-Chain Unsaturated Sphingolipids Mediate Oleate-Induced Rat β-Cell Proliferation. Diabetes. 2022 Mar 14:db210640. BioRxiv link.
- Pronounced proliferation of non-beta cells in response to beta-cell mitogens in isolated human islets of Langerhans. Hasna Maachi, Julien Ghislain, Caroline Tremblay, Vincent Poitout. Sci Rep 11, 11283 (2021).
Free-fatty acid receptor 4 inhibitory signaling in delta cells regulates islet hormone secretion in mice. Marine L. Croze, Marcus F. Flisher, Arthur Guillaume, Caroline Tremblay, Glyn M. Noguchi, Sabrina Granziera, Kevin Vivot, Vincent C. Castillo, Scott A. Campbell, Julien Ghislain, Mark O. Huising, Vincent Poitout. Molecular Metabolism, Article 101166.
Combined deletion of free fatty-acid receptors 1 and 4 minimally impacts glucose homeostasis in mice. Marine L Croze, Arthur Guillaume, Mélanie Ethier, Grace Fergusson, Caroline Tremblay, Scott A Campbell, Hasna Maachi, Julien Ghislain, Vincent Poitout. Endocrinology, bqab002, https://doi.org/10.1210/endocr/bqab002.
- HB-EGF Signaling is Required for Glucose-Induced Pancreatic β-cell Proliferation in Rats.
Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, Metukuri MR, Scott DS, Ghislain J, Poitout V.
Diabetes 2020 March;69(3):369-380.
- The autonomic nervous system regulates pancreatic beta-cell proliferation in adult male rats.
Moullé VS, Tremblay C, Castell AL, Vivot K, Ethier M, Fergusson G, Alquier T, Ghislain J, Poitout V.
Am J Physiol Endocrinol Metab. 2019 August;317(2):E234-E243.
- Deletion of Protein Kinase D1 in Pancreatic β-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice.
Bergeron V, Ghislain J, Vivot K, Tamarina N, Philipson LH, Fielitz J, Poitout V.
Diabetes. 2018 Jan;67(1):71-77.
- Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats.
Moullé VS, Vivot K, Tremblay C, Zarrouki B, Ghislain J, Poitout V.
Diabetologia. 2017 May;60(5):879-888.
- The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.
Bergeron V, Ghislain J, Poitout V.
Islets. 2016 Nov;8(6):157-164. - The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.
Vivot K, Moullé VS, Zarrouki B, Tremblay C, Mancini AD, Maachi H, Ghislain J, Poitout V.
Mol Metab. 2016 Aug 26;5(10):988-996. - Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.
Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attané C, Moullé VS, MacDonald PE, Ghislain J, Poitout V.
J Clin Invest. 2016 Sep 1;126(9):3598-612. - Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry.
Ghislain J, Fontés G, Tremblay C, Kebede MA, Poitout V.
Endocrinology. 2016 Mar;157(3):1299-306.
- The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice.
Fontés G, Ghislain J, Benterki I, Zarrouki B, Trudel D, Berthiaume Y, Poitout V.
Diabetes. 2015 Dec;64(12):4112-22. - β-Arrestin Recruitment and Biased Agonism at Free Fatty Acid Receptor 1.
Mancini AD, Bertrand G, Vivot K, Carpentier É, Tremblay C, Ghislain J, Bouvier M, Poitout V.
J Biol Chem. 2015 Aug 21;290(34):21131-40.
- Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice.
Fergusson G, Ethier M, Guévremont M, Chrétien C, Attané C, Joly E, Fioramonti X, Prentki M, Poitout V, Alquier T.
Mol Metab. 2014 Sep 28;3(9):848-54. - Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines.
Semache M, Ghislain J, Zarrouki B, Tremblay C, Poitout V.
Islets. 2014;6(4):e982376. - Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.
Zarrouki B, Benterki I, Fontés G, Peyot ML, Seda O, Prentki M, Poitout V.
Diabetes. 2014 Mar;63(3):982-93.
- A model of chronic nutrient infusion in the rat.
Fergusson G, Ethier M, Zarrouki B, Fontés G, Poitout V.
J Vis Exp. 2013 Aug 14;(78). - Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells
Semache M, Zarrouki B, Fontés G, Fogarty S, Kikani C, Chawki MB, Rutter J, Poitout V.
J Biol Chem. 2013 Aug 23;288(34):24825-33.
- G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.
Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V.
Diabetologia. 2012 Oct;55(10):2682-2692. - Lipopolysaccharides impair insulin gene expression in isolated islets of Langerhans via Toll-Like Receptor-4 and NF-κB signalling.
Amyot J, Semache M, Ferdaoussi M, Fontés G, Poitout V.
PLoS One. 2012;7(4):e36200. - Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1.
Kebede M, Ferdaoussi M, Mancini A, Alquier T, Kulkarni RN, Walker MD, Poitout V.
Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2376-81.
- Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.
Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V.
J Mol Endocrinol. 2011 Sep 30;47(3):273-83.
- Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
Fontés G, Zarrouki B, Hagman DK, Latour MG, Semache M, Roskens V, Moore PC, Prentki M, Rhodes CJ, Jetton TL, Poitout V.
Diabetologia. 2010 Nov;53(11):2369-79. - Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity.
Fontés G, Hagman DK, Latour MG, Semache M, Poitout V.
Diabetes Res Clin Pract. 2010 Mar;87(3):322-8.
Reviews and Commentaries
(2010-2021)
- Targeting lipid GPCRs to treat type 2 diabetes mellitus — progress and challenges
Julien Ghislain & Vincent Poitout.
Nature Reviews Endocrinology (2021).
- A Call for Improved Reporting of Human Islet Characteristics in Research Articles.
Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM.
Diabetes. 2019 Feb;68(2):239-240. - A call for improved reporting of human islet characteristics in research articles.
Poitout V, Satin LS, Kahn SE, Stoffers DA, Marchetti P, Gannon M, Verchere CB, Herold KC, Myers MG Jr, Marshall SM.
Diabetologia. 2019 Feb;62(2):209-211.
- Fatty Acids and Insulin Secretion: From FFAR and Near?
Poitout V.
Diabetes. 2018 Oct;67(10):1932-1934. - Considerations and guidelines for mouse metabolic phenotyping in diabetes research.
Alquier T, Poitout V.
Diabetologia. 2018 Mar;61(3):526-538.
- Nutrient regulation of pancreatic β-cell proliferation.
Moullé VS, Ghislain J, Poitout V.
Biochimie. 2017 Dec;143:10-17. - The Role and Future of FFA1 as a Therapeutic Target.
Ghislain J, Poitout V.
Handb Exp Pharmacol. 2017;236:159-180.
- CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression?
Koppe L, Poitout V.
Trends Endocrinol Metab. 2016 Jul;27(7):439-440.
- GPR40 agonists for the treatment of type 2 diabetes: life after ‘TAKing’ a hit.
Mancini AD, Poitout V.
Diabetes Obes Metab. 2015 Jul;17(7):622-9.
- Modulating GPR40: therapeutic promise and potential in diabetes.
Poitout V, Lin DC.
Drug Discov Today. 2013 Dec;18(23-24):1301-8. - The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?
Mancini AD, Poitout V.
Trends Endocrinol Metab. 2013 Aug;24(8):398-407. - Lipotoxicity impairs incretin signalling.
Poitout V.
Diabetologia. 2013 Feb;56(2):231-3. doi: 10.1007/s00125-012-2788-6. Epub 2012 Nov 28.
- Glucolipotoxicity of the pancreatic beta cell.
Poitout V, Amyot J, Semache M, Zarrouki B, Hagman D, Fontés G.
Biochim Biophys Acta. 2010 Mar;1801(3):289-98.